Sunday, January 26, 2020
Carbonic Anhydrase The Fastest Enzyme Biology Essay
Carbonic Anhydrase The Fastest Enzyme Biology Essay Carbonic anhydrase, abbreviated as CA, is the first identified zinc containing enzyme, (CA; carbonate hydro-lyase, EC 4.2.1.1) It is an enzyme that catalyzes the reversible hydration and dehydration of carbon dioxide to form carbonic acid, bicarbonate ions and protons. Being one of the fastest enzyme known, it is believed that one molecule of CA can process one million molecules of carbon dioxide per second. The basic molecular structure of CA includes specific amino acid threonine 199, glutamate 106, histidine 64 and histidine residues namely His 93, His 95, and His 118. The mode of regulation of CA is being inhibited by various medically prescribed substances that act as non competitive inhibitors, an example is Acetazolamide. CA plays a major key role in the fluid balance and regulatory of pH in different parts of the body thus, Mutation of this enzyme may lead to several diseases.(1) CARBONIC ANYHYDRASE THE START: Breathing, a fundamental function in life The air that we breathe in has some valuable oxygen, an important molecule wherein it helps the breakdown of fats and sugars in our cells. From the blood, oxygen diffuses then binds with the hemoglobin to be transported in the cells of our body. A by product of sugar and fat breakdown in cells is called Carbon dioxide CO2). It is a key metabolite in all living organism and it needs to be removed from our body. Carbon dioxide is diffuse out of the cells and transported in the blood in different ways to get to the lungs. CA is transported in numerous forms, mainly as bicarbonate, HCO3-. Bicarbonate is a CO2- with an attached OH group. When the HCO3- reaches the lungs, it is transformed back to a CO2, so it can be exhaled from the body. The conversion of bicarbonate to carbon dioxide facilitates its transport into the cell; while the conversion of carbon dioxide to bicarbonate assists trap the carbon dioxide in the cell. This interconversion of carbon dioxide and bicarbonate develop at a slow physiological pH hence organism tend to produces an enzyme to hasten the process. This enzyme responsible for the speed up interconversion, which can be found in the red blood cells, is called carbonic anhydrase. Although the interconversion of bicarbonate to carbon dioxide can happen without the enzyme, CA can great increase the rate of the conversions up to a millions of fold. (2) STRUCTURE The CA molecule in general has ellipsoidal shape with the estimated dimension 4.1 x 4.1 x 4.7 nm. The active site is situated in a cavity having an approximately conical shape. The cavity is assessed 1.5 m wide at the way in and about 1.6 nm deep attaining almost the center of the molecule. The zinc ion is next to the peak of the cone and liganded into 3 imidazole groups. Figure 1. CA Structure (2) Figure 1. shows the structure of CA. Taken as a whole, is composed of 10-stranded anti-parallel beta-sheet enclosed with various elements of other secondary structure. The 6 alpha-helices and 10-beta sheets make up the secondary structure of carbonic anhydrase. The basic function of CA is basically to regulate the oxygen and carbon dioxide content of the blood that is needed in a human body. As the function suggests, the chemical structure of CA extremely lies with the presence of zinc that lies deep within its active site. Its common amino acid composition includes threonine, glutamate and histidine. The specificity of these 3 amino acids (threonine 199, glutamate 106, and histidine 64) plays a critical role in relation to the presence of zinc by charging it with a hydroxyl ion. The zinc cation is associated with three histidine residue protein backbone namely: His93, His95, and His118. As stated, zinc plays a major role in the reaction of CA. The zinc present in the active side of CA is being bound to water to be able to dissociate it into a proton and hydroxyl ion. The hydroxyl ion is being stabilized by the positively charged zinc, in this way; the hydroxyl ion is being prepared to attack the carbon dioxide inside the RBC. A closer look with CA can be seen in the figure below where the amino acid chains in the active site together with the zinc are evident. The role of the zinc basically includes the command of directional transfer of the bound hydroxyl to the carbon dioxide to be able to form bicarbonate ion. From the figure, it shows that the intermediate structure where the bicarbonate ion is still attached to the enzyme. The alanine replicated the side chain for amino acid 199 in this arrangement. Histidine 64 swings in the direction of and away from the zinc ion in every cycle of enzyme action although it is helping the zinc to recharge with a novel hydroxyl ion. The two locations of this residue, revealed in the bottom right figure, symbolize its movement throughout the action of enzyme. Almost immediately as the zinc is reloaded with an original water molecule together with the release of bicarbonate ion, the enzyme is set for another action on some new carbon dioxide molecule. (3) MECHANISM OF CATALYSIS The rate of catalysis of the CA is exceedingly pH dependent. It means that, the higher the pH, the catalysis is faster and as the pH reduces, the speed of the reaction falls down. The mean pH of this transition is near pH 7. (5) Figure 2. Mechanism of CA catalysis (6) Figure 2.0 shows the mechanism of CA catalysis. A zinc atom which is generally bound to four or more ligands differs in CA. In CA, three locations are occupied by imidazole ring of three histidine residues and an additional site is occupied by a water molecule. Thus the geometry form of the active site is tetrahedral. The zinc atom plays an important role in the mechanism of CA catalysis because it is responsible for the release of a proton H+ from a water molecule, which then generates a nucleophilic hydroxide ion. Then the carbon dioxide substrate will attach to the active site of the enzyme to react with the ion of hydroxide. The zinc-bound OH- attacks the carbon of CO2 therefore converting it into a bicarbonate ion. This occurs since the zinc ion has the +2 charge, which attracts the oxygen of water. It then deprotonates the water, thus, converting it into a better nucleophile so that the newly converted hydroxyl ion can attack the carbon dioxide. After the nucleophilic att ack of zinc bound OH-, addition of water molecule displaces the bicarbonate ion from the metal ion. The CA is then ready for another cycle of catalysis. (7) KINETICS OF REACTIONS CA inhibitors are class of pharmaceuticals that control the activity of carbonic anhydrase. It is inhibited by two classes of compounds, a metal complex forming anions and others are isosteres and sulfonamides. Inhibitors ionize upon binding with the enzyme to give way an NH- group that relocates the zinc hydroxide ions and shares a hydrogen bond. There are roughly 25 clinically used CA inhibitors as a drugs. It is mainly established as antiglaucoma drugs, diuretics, hypotensive agents, anticonvulsants, anticancer agents, antiepileptics, with additional use in the management of duodenal and gastric ulcers, osteoporosis and neurological disorder. (8) Acetazolamide Methazolamide Dorzolamide Topiramate Figure 3. Illustrations of some CA inhibitors (9) Figure 3.0 shows some CA inhibitors like Acetozolamide which acts as a mild diuretic. It cures glaucoma, altitude sickness, and some benign intracranial hypertension. Methazolamide treats glaucoma present in dogs which is called Open-angle glaucoma. While Topiramate which is a weak inhibitor, alleviate epilepsy, lennox gastuat syndrome and migraine headaches. And another CA inhibitor is the, Dorzolamide or sulphonamide which treat ocular hypertension or open-angele glaucoma. (10) CA activator regulates the proton transfer processes between the active site and the solvent system. It also binds at the entrance of the enzyme of the active site. One of the strong activator of CA is Histidine. Some amines and amino acids like l-Trp (tryptophan), l-Phe (Phenylalanine), d-DOPA (D- 3,4-dihydroxyphenylalanine), l-Tyr (Tyrosine), 4-amino-l-Phe also works as activators of CA. These CA activators are potentially target for drug development that can be useful as a derivative for the enhancement of synaptic efficacy which can be able to treat various conditions like, depression, alzheimers disease, ageing, spatial learning and memory therapy enhancer. (11) MODE OF REGULATION: Acetazolamide Inhibitor In case of excessive contents of CA in blood and peripheral areas of the lungs, proper regulation and inhibition is needed. Acetazolamide is a non competitive inhibitor that is effective in giving control with the catalytic reaction of the enzyme. This chemical complex substance is medically used o treat different conditions of moderate up to severe metabolic or respiratory alkalosis. Alkalosis may happen if excess CA is being reacted with the bicarbonate and carbon dioxide ions in the RBC, causing extreme absorption of bicarbonate thus giving the erythrocyte more basicity rather than having enough and sufficient pH level. Acetazolamide action is explained by interfering with bicarbonate (HCO3-) reabsorption in the kidneys, thereby giving enough acidity in the RBC, and further results to alkalinizing the urine. The action of inhibition results further to decreased synthesis of aqueous humor of the eye and causes the lowering of intraocular pressure. The interaction of Acetazolamide with CA does not occur with the active site, only close or remote to the active site. The net effect of this inhibitor basically changes the shape of CA that obviously leads to the inability of the substrate to bind properly, results to no catalytic reaction. (12) CARBONIC ANHYDRASE IN HEALTH AND DISEASE: Carbonic Anhydrase is found in numerous places in the body, including in the cerebro-spinal fluid, cytosol of some cells and mainly in the red blood cells. Since CA generates and utilizes protons and bicarbonate ions, it plays a major key role in the fluid balance and regulatory of pH in different parts of the body. Absence or mutation of the CA enzyme may lead to several diseases. Also, CA inhibitor contributes to several treatments of diseases. One of the linked diseases of CA is the Osteopetrosis with cerebral calcification and renal acidosis. It is a syndrome deficient with CA in the body commonly called as Marble brain disease. This happens because sulfonamide inhibitor of CA can produce metabolic acidosis and have shown that CA inhibitors blocks the parathyroid hormone-induced the release of calcium bone which causes bone resorption. And since CA is present in the brain and CA inhibitors inhibits the production of cerebral spinal fluid, mutation of CA lead to cerebral calcification. Other disease associated with the deficiency of specific type of CAIII is the Myastenia gravis. It is an autoimmune neuromuscular disorder that results to a weak muscle of a person. Defects in CA IV can cause retinitis pigmentosa, a degeneration of retinal photoreceptor, which a patient experiences night vision blindness and loss of midperipheral visual. (13) Glaucoma, a condition wherein a build up of fluid in the eyes occurs and this presses the optic nerve that caused damage, is treated with the use of CA inhibitors like acetazolamide, brinzolamide, dorzolamide, and methazolamide. These inhibitors lessen the amount of fluid in the eye rapidly by 40% to 60% thus lowering the pressure inside the eye of a person with glaucoma. It now lessens the risk of optic nerve damage which promote vision loss. But prolong use of this drug affects the same enzyme in the tissue and may lead to kidney and liver damage The CA also plays an important role in the secretion of acid through the catalyzed hydration of excreted CO2 in the stomach lining which is mainly responsible in digestion of food. It helps to make pancreatic juice alkaline and our saliva neutral. In summary, CA performs different role and functions at their specific locations. (14)
Saturday, January 18, 2020
Acct553 Homework Es
1. (TCO A) A taxpayer may litigate a tax dispute without first paying the tax in the: (Points : 5)|        U. S. District Court. U. S. Tax Court. U. S. Court of Federal Claims. All of the above | 2. (TCO F) A business bad debt is deductible for tax purposes as a(n): (Points : 5)|        ordinary business deduction. short-term capital loss. long-term capital loss. miscellaneous itemized deduction. | 3. (TCO I) Under the cash method of tax accounting, tax deductions are generally taken when: (Points : 5)|        payment is made. the liability arises. there is net income to absorb the expense.None of the above | 4. (TCO A) Which of the following constitutes tax evasion? (Points : 5)|        Arranging your affairs to keep your tax liability as low as possible under the tax law        Failing to disclose a tax liability from a completed transaction        Trying to maximize profits Trying to minimize your tax liability. | 5. (TCO C) Which of the following items is subject to federal income tax? (Points : 5)|        Interest on U. S. Treasury bonds Gambling winnings Interest on loans made in the ordinary course of business        All of the above | 6. (TCO B) Sam owes Bob $8,000.Bob cancels (forgives) the debt. The cancellation is not a gift, but Sam is insolvent. Which of the following statements is correct concerning the impact of this transaction? (Points : 5)|        Both Bob and Sam recognize $8,000 of taxable income. Bob recognizes $8,000 of taxable income. Sam recognizes $8,000 of taxable income. Neither Bob nor Sam has any taxable income from this transaction. | 7. (TCO I) David, a cash basis taxpayer, owns two rental properties. Based on the following information, compute the amount that he must include in his 2012 gross rental income.Property #1, security deposit on one-year lease received 2/1/12 All of deposit returned at lease end: $1,000 Property #1, payment received 2/1/12 for last month of lease(1/13): $900 Property #1, rental income received in 2012 2/12-12/12: $8,000 Property #2, rental income received in 2012 1/12-12/12: $9,600 Property #2, security deposit received 1/1/12 to be used for last month's rent: $800 Property #2, rent 1/13 received 12/28/12: $800 (Points : 5)|        $21,100 $19,300 $18,500 $20,100 | 8. (TCO F) Section 197's intangible assets, such as patents and trademarks, are amortized for tax purposes over: (Points : 5)| years. 15 years. 10 years. 20 years. | 9. (TCO E) Explain the constructive receipt doctrine. (Points : 17)            | 10. (TCO G) Answer the following questions concerning tax laws. a. What roles do the U. S. Constitution and U. S. Congress play in creating the tax law? b. What does the common body of tax law (CBOTL) consist of? Br iefly explain how a tax bill becomes a tax law. c. What role does the Internal Revenue Service play in interpreting, and providing guidance on, the tax law? What types of tax law guidance are published by the IRS? (Points : 18)            |
Friday, January 10, 2020
Proposal for relationship Essay
The idea was about to show gender inequality through different aspects of people. To do a notch thinking about the topic. The documentary shows different views of what they think of gender inequality or equality. There are interviews that were conducted from different people from different background, races, genders, and status. We have conducted interviews of teachers, politicians general public, a barber, a corporate person and so on. Although the world has become so advanced but there are gender inequalities on high levels. Gender inequality is not just a problem in it slef, it is a major problem for the economy aswell. People still thinks women if start going out for work will get dominant and powerfull over man and if she goes ot, she becomes commercial, people look them with different perspectives. Though they forget, that women are to be respected and treated as she is supposed to and given all her rights. GENDER INEQUALITY Gender inequality refers to unequal treatment or perceptions of individuals based on their gender. It arises from differences in socially constructed gender roles as well as biologically through chromosomes, brain structure, and hormonal differences. Gender systems are often dichotomous and hierarchical; gender binary systems may reflect the inequalities that manifest in numerous dimensions of daily life. Gender inequality stems from distinctions, whether empirically grounded or socially constructed. On differences between the sexes. We will be looking into the following what causes inequality between women and men: how does it arise, why does it take different forms, why does it vary in degree across societies, what are the components that add up to gender inequality, how do various institutions and practices contribute to it, and how does it change? There is a coordination problem in social relations; namely, for interactions between individuals to proceed smoothly, they must be able to synchronize their behavior. In US society, there are many shared category systems used to create â€Å"common knowledge.†However, according to Ridgeway, these categories, â€Å"†¦must be so simplified that they can be quickly applied as framing devices to virtually anyone to start the process of defining self and other in the situation.†If you meet an unfamiliar person, you will, â€Å"automatically and instantly,†categorize them, and your interaction will proceed with this information in mind. In the US, the basic â€Å"primary†cultural categories include sex, race, and age. – In general, men are believed to be especially more competent than women in male-typed settings (e.g. engineering, sports) and positions of authority, while women are advantaged in female-typed settings (e.g. childcare, communicat ion). In mixed sex, gender neutral settings, men are believed to be modestly and diffusely more competent. Even though these beliefs are based are based on the â€Å"average†woman and the â€Å"average†man, they become the â€Å"default rules†for coordinating behavior. So if equally qualified applicants apply for a male-typed job, such as a computer engineer, male applicants will be advantaged relative to female applicants. But if two equally qualified applicants apply to a female-typed job, such as a nanny, the woman would be more likely to receive the job offer. TYPES OF INEQUALITIES Mortality inequality: In some regions in the world, inequality between women and men directly involves matters of life and death, and takes the brutal form of unusually high mortality rates of women and a consequent preponderance of men in the total population, as opposed to the preponderance of women found in societies with little or no gender bias in health care and nutrition. Mortality inequality has been observed extensively in North Africa and in Asia, including China and South Asia. Natality inequality: Given a preference for boys over girls that many male-dominated societies have, gender inequality can manifest itself in the form of the parents wanting the newborn to be a boy rather than a girl. There was a time when this could be no more than a wish (a daydream or a nightmare, depending on one’s perspective), but with the availability of modern techniques to determine the gender of the foetus, sex-selective abortion has become common in many countries. It is particu larly prevalent in East Asia, in China and South Korea in particular, but also in Singapore and Taiwan, and it is beginning to emerge as a statistically significant phenomenon in India and South Asia as well. This is high-tech sexism. Basic facility inequality: Even when demographic characteristics do not show much or any anti-female bias, there are other ways in which women can have less than a square deal. Afghanistan may be the only country in the world the government of which is keen on actively excluding girls from schooling (it combines this with other features of massive gender inequality), but there are many countries in Asia and Africa, and also in Latin America, where girls have far less opportunity of schooling than boys do. There are other deficiencies in basic facilities available to women, varying from encouragement to cultivate one’s natural talents to fair participation in rewarding social functions of the community. Special opportunity inequality: Even when there is relatively little difference in basic facilities including schooling, the opportunities of higher education may be far fewer for young women than for young men. Indeed, gender bias in higher education a nd professional training can be observed even in some of the richest countries in the world, in Europe and North America. Sometimes this type of division has been based on the superficially innocuous idea that the respective â€Å"provinces†of men and women are just different. This thesis has been championed in different forms over the centuries, and has had much implicit as well as explicit following. It was presented with particular directness more than a hundred years before Queen Victoria’s complaint about â€Å"woman’s rights†by the Revd James Fordyce in his Sermons to Young Women (1766), a book which, as Mary Wollstonecraft noted in her A Vindication of the Rights of Women (1792), had been â€Å"long made a part of woman’s library.†Fordyce warned the young women, to whom his sermons were addressed, against â€Å"those masculine women that would plead for your sharing any part of their province with us,†identifying the pro vince of men as including not only â€Å"war,†but also â€Å"commerce, politics, exercises of strength and dexterity, abstract philosophy and all the abstruser sciences.†Even though such clear-cut beliefs about the provinces of men and women are now rather rare, nevertheless the presence of extensive gender asymmetry can be seen in many areas of education, training and professional work even in Europe and North America. Professional inequality: In terms of employment as well as promotion in work and occupation, women often face greater handicap than men. A country like Japan may be quite egalitarian in matters of demography or basic facilities, and even, to a great extent, in higher education, and yet progress to elevated levels of employment and occupation seems to be much more problematic for women than for men. In the English television series called â€Å"Yes, Minister,†there is an episode where the Minister, full of reforming zeal, is trying to find out from the immovable permanent secretary, Sir Humphrey, how many women are in really senior positions in the British civil service. Sir Humphrey says that it is very difficult to give an ex act number; it would require a lot of investigation. The Minister is still insistent, and wants to know approximately how many women are there in these senior positions. To which Sir Humphrey finally replies, â€Å"Approximately, none.†Ownership inequality: In many societies the ownership of property can also be very unequal. Even basic assets such as homes and land may be very asymmetrically shared. The absence of claims to property can not only reduce the voice of women, but also make it harder for women to enter and flourish in commercial, economic and even some social activities.2 This type of inequality has existed in most parts of the world, though there are also local variations. For example, even though traditional property rights have favoured men in the bulk of India, in what is now the State of Kerala, there has been, for a long time, matrilineal inheritance for an influential part of the community, namely the Nairs. Household inequality: There are, often enough, basic inequalities in gender relations within the family or the household, which can take many different forms. Even in cases in which there are no overt signs of anti-female bias in, say, survival or son-preference or education, or even in promotion to higher executive positions, the family arrangements can be quite unequal in terms o f sharing the burden of housework and child care. It is, for example, quite common in many societies to take it for granted that while men will naturally work outside the home, women could do it if and only if they could combine it with various inescapable and unequally shared household duties. This is sometimes called â€Å"division of labour,†though women could be forgiven for seeing it as â€Å"accumulation of labour.†The reach of this inequality includes not only unequal relations within the family, but also derivative inequalities in employment and recognition in the outside world. Also, the established fixity of this type of â€Å"division†or â€Å"accumulation†of labour can also have far-reaching effects on the knowledge and understanding of different types of work in professional circles. When I first started working on gender inequality, in the 1970s, I remember being struck by the fact that the Handbook of Human Nutrition Requirement of the World Health Organisation (WHO), in presenting â€Å"calorie requirements†for different categories of people, chose to classify household work as â€Å"sedentary activity,†requiring very little deployment of energy.3 I was, however, not able to determine precisely how this remarka ble bit of information had been collected by the patrician leaders of society. FACTS ABOUT GENDER INEQUALITY The five countries with the best record of gender parity are Iceland, Finland, Norway, Sweden and the Philippines. Iceland holds the top spot for the fifth year in a row and â€Å"continues to be the country with the narrowest gender gap in the world.†The U.S. is at number 23, falling behind several countries that it has tried to bomb or colonize, such as Cuba and Nicaragua, or moralize at, such as Burundi. (Official U.S. government goals in Burundi are â€Å"to help the people of Burundi realize a just and lasting peace based upon democratic principles and sustainable economic development.†) The U.S. also is only at number 17 in gender parity out of the 49 high-income countries that have been measured–a rather poor showing for a country that tops the chart when it comes to high incomes. According to one recent study, incomes among the top 1 percent in the U.S. rose by 31.4 percent between 2009 and 2012, while incomes for everyone else grew just 0.4 percent. This wealth is obviously not going toward ensuring gender equality. China, the emerging economic competitor to the U.S., is at number 69 with a steady deterioration in its gender relations since 2010. China and the U.S. have the greatest number of millionaire households, and China has seen one of the biggest economic booms in recent years. It is thus alarming that in China, just like in the U.S., the sole beneficiaries of this boom has been the rich. The disparity is particularly clear in certain key areas: for instance, the report ranks China at 133, almost to the very bottom of all the countries surveyed, in the Health and Survival category. Indeed, some of the leading affluent nations perform very poorly on the â€Å"Health and Survival†Category. Israel, for example, is at 93 falling below the country it demonizes regularly: Iran! The five countries with the poorest record for gender parity are Mauritania, Syria, Chad, Pakistan and Yemen. Not to let the national ruling classes of these countries off the hook, but it’s important to bear in mind that these countries have all been the victim of devastating imperialist policies and violence from the West. Along with colonialism, drone strikes and International Monetary Fund demands, we can also add the resultant gender disparity to the list of the West’s â€Å"gifts†to these countries. GENDER EQUALITY Gender equality is the measurable equal representation of women and men. Gender equality does not imply that women and men are the same, but that they have equal value and should be accorded equal treatment. The United Nations regards gender equality as a human right. It points out that empowering women is also an indispensable tool for advancing development and reducing poverty. Equal pay for equal work is one of the areas where gender equality is rarely seen. All too often women are paid less than men for doing the same work. This is one of the reasons that the majority of the world’s poor are women: around 70% of the people who live in extreme poverty, on less than US$1 a day, are girls and women. Suffrage (the right to vote) is another area of gender equality that still does not extend to all the women in the world. Saudi Arabia does not give women the right to vote; in the USA right wing commentators say that women should never have been given the right to vote. The impor tance of gender equality is highlighted by its inclusion as one of the 8 Millennium Development Goals that serve as a framework for halving poverty and improving lives. Despite this, discrimination against women and girls (such as gender-based violence, economic discrimination, reproductive health inequities and harmful traditional practices) remains the most pervasive and persistent form of inequality. CONCLUSION Despite modernization and acknowledgment of right, we still see countries facing the problem of gender inequality and let most to suffer from this are developing countries. After the research we can conclude that inequality does not only brings in stress and problems along it but also economically affects. The relationship between economic and gender equality is very clear. there are people who still do not allow women to go ut and work. We still think women are not supposed to go out and work as they go out they will get dominant over men. Girls are removed early from schools. Early marriages. Those who work have a glass ceiling or are not allowed to go on higher posts then men. And so on so forth. If we remove this gender inequality, let the women work educate them, they will not only be contributing with the man to run the house expenses but also help in economy; less dependent people, more bread earning hence a good lifestyle. With such an inflationary economy where prices are go ing up, one person is not enough to earn and feed the family. A women who is educated, can raise her children in a very well-mannered and appropriate way with good moral and ethnic values. A healthy home comes with educated women. BIBILOGRAPHY Amartya Sen. Many faces of gender inequality. FRONTLINE. Volume 18 – Issue 22, Oct. 27 – Nov. 09, 2001 Sex differences in humans . http://en.wikipedia.org/wiki/Gender_inequality Tithi Bhattacharya. Measuring gender inequality. report on the gender gap internationally. from http://socialistworker.org/2013/11/04/measuring-gender-inequality
Thursday, January 2, 2020
Corporate Social Responsibility And Human Rights - 943 Words
CORPORATE SOCIAL RESPONSIBLITY Nicholas S Jones ACED 4050 Valdosta State University March 20, 2016 CORPORATE SOCIAL RESRPONSIBILITY (CSR) Introduction Today, the world faces numerous challenges ranging from dreadful environmental conditions through poverty and human rights, to energy and resource supply issues. Social responsibility policy focuses on using the capabilities of a business to improve lives and sustain our planet through contributions to local communities and society at large. In other words, a business should fully realize it’s potential as an organization to make a better world through corporate self-regulation assimilated into a business module. CSR and Human Rights The global community expects companies to operate with due admiration for human rights. Beyond meeting regulatory requirements and social expectations in areas in which they operate, by proactively presenting more rigorous international standards such as the United Nations Global Compact, companies will reinforce their commitment to human rights. In 1998 the Secretary General of the UN, declared that he â€Å"was building a more solid relationship with the business community. Thriving markets and human security goes hand in hand: without one we will not have the other†(Annan, 1998, p. 1820). Afterwards, a World Economic Forum was held in 1999. At the forum, Kofi Annan introduced what is known the ‘Global Compact’. 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